Speaking in the February issue of Town and Country magazine, the flame-haired hunk said: "This is where I feel more like myself than anywhere else in the world.
"I have this intense sense of complete relaxation and normality here."
And Harry - who is currently dating American actress Meghan Markle - has revealed ever since his first trip to Africa with his family in 1997 he has held a fondness in his heart.
He said: "I first came in 1997, straight after my mum died. My dad told my brother and me to pack our bags -- we were going to Africa to get away from it all."
And Harry has revealed he wishes he could visit Africa - where he has been working to help endangered elephants - more often.
He said: "I wish I could spend more time in Africa."
And Harry, who set up the charity Sentebale in memory of his late mother, has admitted he is proud of his achievements with the organisation and has teased he plans to work on more projects in the future.
Speaking previously, he said: "Now, I can see exactly where I want to take it. The fact that I've managed to keep Sentebale going ... for the last 10/11 years has been fantastic because now everything else I'm involved with makes sense to me and I'm just getting started.
"What started as an idea of me turning round and saying, right, I've got a year off, I want to do something really constructive with my life, want to do something that makes my mother proud.
"Someone said, right, go to Lesotho, it's like where the hell is that? Now I can see exactly where I want to take it. I have huge amounts of passion for the causes and interests and charities I'm involved with."