Washington - Women deficient in vitamin D at the time of a breast cancer diagnosis are more likely to die or see the tumour spread, a Canadian study published in the United States has shown.
Patients low in vitamin D were 94 percent more likely to see their cancer metastasise and 73 percent more likely to die from it, compared to women with normal levels of vitamin D in their blood, researchers found.
And many of the 512 breast cancer patients participating in the research, published Thursday in the American Society of Clinical Oncology, had inadequate vitamin D to begin with.
Some 37.5 percent of the women were "deficient" in vitamin D and 38.5 percent had "insufficient" levels of the vitamin, which is considered key to bone health.
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But investigators stopped short of recommending taking vitamin D supplements to reduce the risk of developing breast cancer or dying from it, saying more research needs to be done.
"We were concerned to find that vitamin D deficiency was so common in women diagnosed with breast cancer and that very low vitamin D levels adversely affected patient outcome," said Pamela Goodwin of the University of Toronto, lead author of the study.
"Our results need to be replicated in other clinical studies," she cautioned. "These data indicate an association between vitamin D and breast cancer outcome, but we can't say at this time if it is causal."
Researchers studied 512 women with a median age of 50 diagnosed with breast cancer in Toronto between 1989 and 1995. The women were followed until 2006, over a median period of 11.6 years.
Just 24 percent had adequate blood levels of vitamin D at the time of their diagnosis.
According to Goodwin, a normal level of vitamin D is 80 to 120 nanomoles per litre (nmol/L) of blood. Less than 50 nmol/L is considered deficient.
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