Major breakthrough in battle against cancer

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iol lif jan 11 cancer ribbon REUTERS

London - A major breakthrough in the battle against female cancer was signalled with the emergence of a single test to detect three different types of the disease.

Based on the existing smear test for cancer of the cervix, it also checks for the disease in the ovaries and the womb.

The test is under development by scientists in the US and is expected to be simple and relatively cheap.

Helping to detecting ovarian cancer – dubbed “the silent killer” – would be a significant breakthrough. It exhibits no symptoms in its early stages and is usually not diagnosed until it is too late, proving fatal in two-thirds of cases.

Cancer of the lining of the womb, or endometrial cancer, is easier to spot but still claims 1,400 lives annually.

The new research builds on the success of the smear test, which looks for abnormalities in cells in the cervix, the entrance to the womb.

The five-minute procedure is offered every three years to women aged 25 to 49 and then every five years up to 65. It is credited with cutting cases of cervical cancer by three-quarters since it was introduced. Until now there has been no reliable screening for ovarian and endometrial cancers.

Researchers at John Hopkins Kimmel Cancer Centre in Baltimore, Maryland, identified abnormal genes found in specific types of cancerous cells.

Examining cervical smear samples, they looked for cancerous cells from the ovaries or the womb that had broken off and reached the cervix.

The method had a 100 percent success rate in detecting endometrial cancer, and a 40 percent rate in ovarian cancer. Cancers were detected in both the early and late stages.

No women who were in fact healthy were falsely diagnosed with cancer. The success rate for ovarian cancer may seem low, but the test may still detect cases that would not otherwise be spotted until too late.

Writing in the journal Science Translational Medicine, researchers said testing for more genes might give a better result.

More research including large-scale trials is needed before the PapGene test, as it is known, is ready for the market. It will be at least a decade before it is widely available.

Hazel Nunn of Cancer Research UK said: “Such promising results warrant research on a larger scale to see if this approach could pick up these diseases in the early stages when the chances of survival are best.”

Gilda Witte, chief executive of Ovarian Cancer Action, said: “This is very promising news indeed.” But she added a note of caution that the research is at an early stage and women need to be aware of ovarian cancer symptoms.

The main symptoms are persistent stomach pain and bloating, difficulty eating or feeling full quickly and the need to urinate more often. - Daily Mail

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