The strike, over salaries and working conditions, started on Wednesday morning.
"The national bus strike is set to inconvenience the country in proportions not witnessed before. A lot of people around this time are commuting by road to be with families. The stakes are high and all assistance, particularly from law enforcement agencies, is required so that the safety of road users is not compromised," said committee chairwoman Dikeledi Magadzi.
Dikeledi called on strict policing of permits and licences by traffic authorities, adding that "unscrupulous operators" could exploit the situation by transporting passengers in unroadworthy and uncertified vehicles.
"The taxi industry, long- and short-distance, will be under a lot of pressure. Hence drivers should exercise caution and at all times stick to the rules of no overloading and no speeding," she said.
"Road fatalities in our country are unbelievably high and that should not continue."
The strike follows talks between unions and bus companies deadlocking at the Commission for Conciliation, Mediation and Arbitration (CCMA). Unions are seeking a 12 percent increase while employers are offering 7.5 percent.