Test of Ebola vaccine ‘promising’

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IOL pic july3 lab tests hand glove Independent Newspapers Unlike antigens in some other early-stage Ebola vaccines, Immunovaccine's antigen does not use a live virus to carry the vaccine into cells.

Winnipeg, Manitoba - Four monkeys survived the Ebola virus after being injected with a vaccine that included Immunovaccine's technology, the tiny Canadian company said on Monday, and the announcement sent its stock soaring.

The Halifax, Nova Scotia-based company said four monkeys received the vaccine and later survived a dose of Ebola virus that normally would have been lethal. Two other animals that did not receive the vaccine died within a week.

Immunovaccine, which had a market capitalisation of about C$77-million as of Friday, is one of a handful of companies involved in testing potential vaccines for the Ebola virus, which has killed nearly 1 500 people in West Africa.

Its Ebola program started a few months ago, after the US National Institutes of Health asked Immunovaccine to apply technology from the company's anthrax vaccine to Ebola. The work was part of NIH tests on possible antigens, substances that cause the immune system to produce antibodies against Ebola.

Unlike antigens in some other early-stage Ebola vaccines, Immunovaccine's antigen does not use a live virus to carry the vaccine into cells.

The company has not disclosed the nature of its antigen.

Generally, it “presents those vaccines to the immune system in a slightly different way so that the immune system processes the vaccine a lot better, and as a result produces stronger immunity to that target,” Chief Executive Marc Mansour said in an interview.

He said the company is exploring options to develop the vaccine with various organisations, but would not identify them. Assuming it strikes the partnerships it needs to continue development, clinical trials could start as early as next year, he said.

Other companies testing Ebola vaccines include US-based NewLink Genetics, which holds the licence for a vaccine developed by the Canadian government, privately held Profectus BioSciences and British drugmaker GlaxoSmithKline.

Immunovaccine is also developing therapies for cancer. - Reuters

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