Sharks coach Robert du Preez could make several changes to the side that beat the Waratahs, with several youngsters set to start.
The fairy tale run had to come to an end at some stage. After winning the last three tournaments, the Blitzboks lost in the Canada Sevens final.
Stormers coach Robbie Fleck says the errors in Saturday's Super Rugby match against the Kings were just "teething problems".
The Springbok Sevens will take on USA in the last-four clash at eight minutes after midnight on Monday (12.08am).
The Springbok Sevens team on Saturday topped pool A of the HSBC Vancouver Sevens and will face hosts Canada in the Cup quarter-finals.
"Go on, admit it. You feared, like me, that without Seabelo Senatla and Kwagga Smith, Las Vegas would be a bridge too far for the BlitzBoks."
Bidvest Wits coach Gavin Hunt says his side's exhausting schedule will be no excuse for defeat in Wednesday's Nedbank Cup clash.
Super Rugby’s future structure and format will be announced in the “coming days”, governing body Sanzaar said.