Great Britain's Andy Murray. Photo: Tony O'Brien/Reuters

Andy Murray suffered one of the most embarrassing defeats of his career, as the world number one slumped to a stunning Queen's Club first-round exit against Australia's Jordan Thompson on Tuesday.

Murray was hoping to warm up for his Wimbledon title defence by winning the Queen's title for a sixth time, but instead he succumbed to an astonishing 7-6 (7/4), 6-2 defeat against the world number 90.

The 30-year-old's loss was all the more remarkable because Thompson was only called up to face Murray at the last minute.

Murray was scheduled to face Aljaz Bedene, but he withdrew with a wrist injury just hours before Tuesday's match, leaving Thompson, who was at the west London venue as an alternate after losing in the qualifying rounds, to scramble to get ready for his unexpected date with destiny.

With the Queen's champion well below his best, 23-year-old Thompson seized his opportunity in memorable fashion and handed Murray his earliest exit from the tournament since 2012.

The shock loss ended Murray's 14-match winning streak on grass and his 10-match unbeaten run at Queen's.

After reaching the French Open semi-finals to raise hopes that he was finally back on track following a poor first half of the season, Murray will head to Wimbledon, which starts on July 3, with fresh doubts about the state of his game.