The suspects entered through the student centre before making their way into the computer centre in the design building and left in three vehicles with the computers.
CPUT spokesperson Lauren Kansley said police were also investigating the incident reported on Friday night at the District Six campus.
“We’ve reported the theft of around 50 computers from a building at our D6 campus. Police are already following up on a number of leads and our internal investigations are also under way,” she said.
Police spokesperson Noloyiso Rwexana said there had not been any arrests.
Last year the institution boosted its security after an increase in break-ins, especially at the open-access District Six campus.
The institution announced an estimated R4 million security upgrade at all its campuses.
The appointment of consultants to install CCTV and access control systems at all campuses was also done to manage theft and safety concerns.
A suspect was arrested after being caught with two computers stolen from a building on campus.