Oprah Winfrey (Photo by Chris Pizzello/Invision/AP)

Oprah Winfrey has paid tribute to her mom and thanked fans for their messages following her passing.

The 64-year-old media mogul's mom Vernita Lee passed away on Thanksgiving at her home in Milwaukee, Wisconsin, at the age of 83, and the talk show legend has now thanked fans for their support and sympathy after the news was made public.

Oprah shared a family photo on Instagram and wrote: "Thank you all for your kind words and condolences regarding my mother Vernita Lee's passing. It gives our family great comfort knowing she lived a good life and is now at peace."

Vernita - who worked as a housekeeper throughout her life - has already been laid to rest at a private funeral.

Vernita gave birth to Oprah at the age of 14, shortly after meeting the 'Wrinkle in Time' star's father. But she subsequently moved to Milwaukee to become a maid, meaning the American icon was raised by her grandmother.

The duo had a distant relationship until later in Oprah's life, and they eventually appeared together on the star's eponymous talk show in 1990.

As well as Oprah, Vernita is survived by her other daughter, Patricia Amanda Faye Lee, four grandchildren - Alisha Hayes, Chrishaunda Lee Perez, Aquarius Lofton and Andre Brown - and four great-grandchildren - Jaxon Praise Perez, Chai Theresa Perez, Donovan Hayes and Trinity Hayes.