According to a study, led by researchers from Bambino Gesu Hospital in Italy, dietary fructose increases serum uric acid concentrations.
Both uric acid concentration and fructose consumption may be high in individuals with non-alcoholic fatty liver disease (NAFLD) – a condition where extra fat is accumulated in liver cells in people who drink little or no alcohol.
It is estimated to affect up to 30 per cent of the general population in Western countries and up to 9.6 per cent of all children and 38 per cent of obese children across a spectrum of liver disease, including NASH (defined as steatosis, hepatocyte ballooning and inflammation).
Although NASH is a less aggressive form of NAFLD, it can progress to severe fibrosis and cirrhosis, with development of hepatocellular carcinoma in adults.
The findings suggested that fructose consumption was independently associated with high uric acid, which occurred more frequently in patients with NASH than in not-NASH patients.
"It is plausible that dietary fructose intake and uric acid concentrations are potential risk factors for liver disease progression in NAFLD," said Valerio Nobili from Bambino Gesu Hospital in Italy.
"The study shows for the first time that uric acid concentrations and dietary fructose consumption are independently and positively associated with NASH," Nobili added.
For the study, reported in the Journal of Hepatology, the team analysed 271 obese children and adolescents with NAFLD – 155 males, mean age 12.5 years – who underwent liver biopsy.
Nearly 90 per cent were found drinking cooldrinks and soft drinks one or more times a week. Almost 95 per cent of patients regularly consumed morning and afternoon snacks consisting of crackers, pizza and salty food, biscuits, yogurt, or other snacks.
The development of NASH may markedly affect life expectancy and quality of life in affected individuals.Thus, "it is crucial to understand the risk factors for NASH in children and adolescents in order to design effective interventions," Nobili said.