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Ebola: WHO experts decide on untested drugs

Newspaper articles about West Africa's Ebola outbreak are seen in the city of Monrovia, Liberia. Picture: Jonathan Paye-Layleh

Newspaper articles about West Africa's Ebola outbreak are seen in the city of Monrovia, Liberia. Picture: Jonathan Paye-Layleh

Published Aug 12, 2014


Geneva -

A panel of medical experts determined that it is ethical to provide experimental treatments to patients infected with the deadly Ebola virus, the World Health Organisation said on Tuesday as the global death toll topped 1 000.

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“In the particular circumstances of this outbreak, and provided certain conditions are met, the panel reached consensus that it is ethical to offer unproven interventions with as yet unknown efficacy and adverse effects, as potential treatment or prevention,” the UN's health agency said in a statement.

There is currently no available cure or vaccine for Ebola, and the WHO has declared the latest outbreak a global public health emergency.

But the use of an experimental drug called ZMapp on two Americans and a Spanish priest infected with the virus while working in Africa has opened up an intense ethical debate.

The drug, which is in very short supply, has reportedly shown promising results in the two Americans, but the priest has died, the Spanish hospital where he was being treated said on Tuesday.

US company Mapp Biopharmaceutical which makes the drug said on Monday it had sent all its available supplies to West Africa.

Medical experts from around the world took part in WHO-hosted discussions on Monday to draft guidelines for using non-authorised medicines in emergencies such as Ebola.

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“Ethical criteria must guide the provision of such interventions,” the panel found, stressing the need for “transparency about all aspects of care, informed consent, freedom of choice, confidentiality, respect for the person, preservation of dignity and involvement of the community”.

The panel of experts also emphasised the “moral obligation to collect and share all data generated, including from treatments provided for 'compassionate’ use”, meaning access to an unapproved drug outside of a clinical trial.

The disease has infected 1 848 people and caused 1 013 deaths since early this year, according to latest figures from the WHO, which says it is worst outbreak since Ebola was discovered four decades ago.

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The deadly outbreak has until now been limited to Guinea, Liberia, Sierra Leone and Nigeria, all countries in West Africa where ill-equipped and fragile health systems are struggling to cope. - Sapa-AFP

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