The ANC’s national general council has resolved that South Africa must withdraw from the International Criminal Court (ICC).
Many believe that the body is biased against Africa.
The decision follows a dispute earlier this year over South Africa’s failure to arrest Sudanese president Omar al-Bashir.
The ICC has a warrant of arrest out for him on charges of masterminding genocide in Sudan’s Darfur region.
South Africa Minister in the Presidency Jeff Radebe at the time said that leaving the ICC would be a last resort until all remedies had been exhausted.
There are legal implications for the country leaving the ICC and they will be discussed at a meeting with the body next month.
The ANC’s commission on international relations also discussed the United Nations refusal to extend the permanent membership of its Security Council to Africa.
South Africa wants African countries to have to seats on the council.
“We will continue to campaign for it,” said International Relation Minister Maite Nkoana-Mashabane said.
The commission also called for political challenges to have political solutions.