ER24 spokesperson Russel Meiring said ER24 paramedics, along with several other services, are currently on the scene treating and triaging the patients.
"Initial reports show that approximately 20 people had sustained injuries ranging from minor to critical. Paramedics are treating the patients and will thereafter transport them to nearby hospital for further treatment.
"The ER24 Oneplan Helicopters are currently on the scene to airlift any critical patients to hospital.
The plane was marked Martin's Air Charter, but no information was immediately available about the air company.
"I can only confirm that yes we do have a plane that crashed… on the Moloto Road," local government emergency services spokesperson Johan Pieterse told AFP.
The details surrounding this incident are not yet known.