Shortly before 10am, paramedics from ER24 and other services arrived on the scene where they found the bus and the truck had crashed into a vehicle dealership on the side of the road, ER24 spokesman Werner Vermaak said.
"It is understood that the bus and the truck collided at the intersection whereafter both vehicles crashed into the nearby dealership," he said.
Three people on the bus were treated for moderate injuries on the scene. They were later transported to Tshwane District Hospital.
"Sadly, the driver of the bus succumbed to his injuries. There was nothing that paramedics could do for him and he was declared dead on the scene. The driver of the truck was also treated for moderate injuries and transported to the same hospital."
The cause of the collision was unknown at this stage, Vermaak said.