Police officers advise people to take cover near the scene of a shooting near the Mandalay Bay resort and casino on the Las Vegas Strip, Sunday, Oct. 1, 2017, in Las Vegas. Picture: AP Photo/John Locher

Las Vegas - At least two people died early on Monday and 24 were hospitalised with suspected gunshots wounds in Las Vegas, a local hospital spokesperson said, as police investigated reports of an active shooter in the city.

The reports emanated from the Mandalay Bay Casino on the city's famous strip.

One Twitter user posted that the hotel was on lockdown, while another, citing police scanners, said two gunmen who had shot at a bodyguard and police were on the 32nd floor of the hotel.

Witnesses heard numerous gunshots at the casino hotel, where police tactical teams were searching for the attacker, according to reports on CNN and in the New York Times.

It was not immediately clear how many people were injured.

A representative of the Las Vegas Metropolitan Police could not be reached immediately.