The fight is scheduled to take place at Emperors Palace on Saturday, September 21.
The 27-year-old southpaw, who has made significant strides despite having no amateur background, won the vacant IBO belt in September 2017 with a split decision win over Youri Kayembre Kalenga at the same venue.
“I am looking forward to taking on Seferi," said Lerena. "I have watched several of his fights, he's a good and experienced boxer, and I know he will bring his best into the ring. But I will do my best to defend my crown."
His trainer, Peter Smith, said they are ready for the big day. “We are wellprepared and Kevin is working hard at training. Everything is going well and we are looking forward to it.”