LONDON, ENGLAND - JUNE 30: John Isner of the United States plays a forehand return during his Gentlemen's Singles third round match against Feliciano Lopez of Spain on day seven of the Wimbledon Lawn Tennis Championships at the All England Lawn Tennis and Croquet Club on June 30, 2014 in London, England. (Photo by Jan Kruger/Getty Images)

London - John Isner's defeat against Spain's Feliciano Lopez at Wimbledon left the United States with no survivors in the fourth round of the men's or women's singles for the first time since 1911.

Despite blasting down 52 aces, the American went down 6-7(8) 7-6(6) 7-6(3) 7-5 in a third-round match that was stopped on Saturday because of heavy rain.

Earlier, teenager Madison Keys was forced to withdraw from her third-round match against Kazakhstan's Yaroslava Shvedova with a leg injury, having trailed 7-6 6-6 when play was suspended because of poor light on Saturday evening.

World No.1 Serena Williams was unexpectedly beaten in the third round by Frenchwoman Alize Cornet on Saturday - the American five-times champion's earliest exit since 2005.

While Williams has enjoyed plenty of grand slam success in the past decade, the men have struggled to make an impact in the wake of the retirements of Pete Sampras and Andre Agassi.

Andy Roddick's 2003 triumph at the U.S. Open is the last major success for U.S. men's tennis.

Last year was the first time in 101 years that no American man reached Wimbledon's third round.

Isner, at least, avoided a repeat of that sorry statistic. – Reuters