Durban - The M4 Ruth First Highway was closed to traffic on Monday following a serious crash involving three cars.
According to Garrith Jamieson from Rescue Care Paramedics three vehicles collided just after 10am near the uMhlanga off-ramp, affecting both the north and south bound traffic lanes.
Jamieson said the jaws of life was used to extricate a patient who was severely entrapped in the wreckage.
"The Lenmed 1 Aeromedical Helicopter airlifted the severely injured patient to eThekwini Heart Hospital in a critical condition," he said.
Jamieson said three other people were severely injured were treated with advanced life support before being transported to various hospitals in Durban.
Jamieson said the highway would possibly be reopened in another after 1pm.
He said SAPS were on attendance and would be investigating further.
In a separate incident three people were injured on the R61 near Southbroom after the driver of a light motor vehicle lost control resulting in a rollover.
Netcare 911 said three people sustained injuries ranging from minor to moderate.
Once treated both patients were transported by ambulance to hospital for further treatment.