Stan Wawrinka rallied from 5-2 down in the second set to clinch victory over Italian Alessandro Giannessi and reach the third round of the U.S. Open.
Andy Murray and Marcel Granollers had to block out the noise at Arthur Ashe Stadium during their US Open match.
Simona Halep and Lucie Safarova became the first players to start a match under the $150m Arthur Ashe Stadium roof at the US Open.
Kevin Anderson advanced to the third round of the US Open with a straight-sets victory over Canada's Vasek Pospisil.
Garbine Muguruza was once again left to sift through the remains of another failed U.S.
Bernard Tomic courted controversy yet again when he fired lewd comments toward a heckler at the U.S.
Andy Murray has always said he would quite like an indoor grand slam event and at the U.S. Open it seems he has found the next best thing.
Kei Nishikori, glad to be back in New York, where he became Asia's first men's Grand Slam finalist, reached the second round of the US Open.
Novak Djokovic opened the defence of his U.S. Open title with a 6-3 5-7 6-2 6-1 win over Poland's Jerzy Janowicz.