Outspoken actor Charlie Sheen - who is known for his larger-than-life persona - feels as though he can empathise with the actress, who saw her eponymous sitcom axed by ABC in May following a controversial tweet she sent about Valerie Jarrett, a senior adviser to former US President Barack Obama.
Charlie - who was previously fired from 'Two and a Half Men' after he criticised the show's creator Chuck Lorre - explained: "I can relate to that tone of absolute despair because it's not just about herself, it's about the people that she knows she affected as well.
"What I hear in her voice, trying not to focus on the words but the emotion, is I hear the frustration, pain, there's such a sadness there."
The Hollywood veteran said it's "a little bit sad" that Roseanne's tweet - which many critics have claimed was racist - has destroyed her entire legacy.
He told Australia's 'Kyle and Jackie O' radio show: "The thing that is a little bit sad is that when someone does melt, everything good they have ever done that has entertained millions of people is always forgotten."
During the same interview, Charlie also retracted a tweet he sent in May in which he said "good riddance" to 'Roseanne' and called for the return of 'Two and a Half Men'.
The American actor explained that in spite of Roseanne's controversial post, he's always found her to be "nothing but nice".
Charlie - who was earning as much as $1.8 million per episode at the height of the show's popularity - said: "I shouldn't have said 'Roseanne good riddance' because whatever happened she's been nothing but nice to me in the past so that part I would delete."