Charlize Theron will receive the 2019 American Cinematique Award.
The Long Shot actress will be recognised for her "significant contribution" to the movie industry at a special event in California in November.
American Cinematheque chairman Rick Nicita said they were "extremely pleased" to honour the Oscar-winning star for "breaking through outmoded limitations" on female performers and producers.
He said: "The American Cinematheque is extremely pleased to honour Charlize Theron as the 33rd recipient of the American Cinematheque Award at our celebration this year.
"Charlize Theron is making a significant contribution to the art of motion pictures while breaking through outmoded limitations on what an actress and producer can do.