The 22-year-old actress joins the star-studded line-up of spokesmodels for the prestige French cosmetics brand and feels "honoured" to join a line-up of "iconic women" that has included the likes of Julia Roberts, Kate Winslet, Isabella Rossellini, Penelope Cruz and Lupita Nyong'o.
In a statement, she said: "It's a huge honour to be able to represent a brand like Lancôme and join such an incredible line-up of iconic women."
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The brand also admitted that they were excited to have 'The Greatest Showman' star join their prestigious brand.
Lancome Global Brand President Françoise Lehmann added: "We look forward to a joyous future with Zendaya, whose charisma, influence in film, music and fashion is undoubted. Zendaya brings a youthful and a unique approach to beauty that perfectly complements Lancome's vision and creativity."
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The 'Small Foot' star has been named the brand's youngest global ambassador.
Sharing her excitement of the new addition to the beauty brand, Lupita wrote on Instagram: "@Zendaya welcome to the @LancomeOfficial family! (sic)"
Zendaya replied: "Thank you queen @lupitanyongo (sic)"
Zendaya has also teamed up with Tommy Hilfiger for an exclusive Spring 2019 TommyXZendaya capsule collection, and she says that her new range - which is available from size 4 to 24 and features silhouettes and rainbow stripes - is made to empower women.
Zendaya said: "The most important thing to me is that these clothes feel timeless, and whoever puts it on feels powerful and confident.
"I've learned about what it really takes to make a garment. Even something as simple as a plain white tee takes so much more time, people and energy then you'd think, and every job is crucial."