Port Elizabeth - Five people were killed and 23 seriously injured when a bus overturned in Matatiele in the Alfred Nzo district in the Eastern Cape on Friday, Arrive Alive said.

Three women, a man and a girl, believed to be aged four, were killed, provincial Arrive Alive spokesman Tshepo Machaea said.

The injured, including the driver, were taken to the Taylor Bequest hospital in Mount Fletcher.

The driver apparently lost control of the bus, which was travelling from Matatiele town back to the rural areas, around 2pm.