Johannesburg - Offering his condolences to the family of legendary musician Hugh Masekela, President Jacob Zuma said the nation would mourn a man who "kept the torch of freedom alive".
"It is an immeasurable loss to the music industry and to the country at large. His contribution to the struggle for liberation will never be forgotten," Zuma said.
Masekela, known as the "father of South African jazz" who used his music in the fight against apartheid, has died from prostate cancer, his family said on Tuesday. He was 78.
In a career spanning more than five decades, Masekela gained international recognition with his distinctive Afro-Jazz sound and hits such as "Soweto Blues", which served as one of the soundtracks to the anti-apartheid movement.
Following the end of apartheid, he opened the 2010 Fifa Soccer World Cup Kick-Off Concert and performed at the event's opening ceremony in Johannesburg's Soccer City stadium.
"Hugh’s global and activist contribution to and participation in the areas of music, theatre, and the arts in general is contained in the minds and memory of millions," a statement on behalf of the Masekela family said.
"Rest in power beloved, you are forever in our hearts."
His son, Sal, recalled memories of being dragged around the jazz clubs of Manhattan by his father aged just five.
"He would steal the hearts and souls of innocents with a musical storytelling all his own," Sal posted on his Facebook page.
"It was these moments and his choosing to take me around the globe any chance he got, that would come to shape my entire world view."
Masekela's song "Bring Him Back Home (Nelson Mandela)", written while he was in living in exile, called for the release of the-then imprisoned Mandela and was banned by the apartheid regime.
Arts and Culture minister Nathi Mthethwa tweeted: "A baobab tree has fallen, the nation has lost a one of a kind."
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After honing his craft as a teenager, Masekela left South Africa aged 21 to begin three decades in exile.
His global appeal hit new heights in 1968 when his instrumental single "Grazin' in the Grass" went to number one in the U.S. charts.
As well as close friendships with jazz legends like Miles Davis, John Coltrane and Charlie Mingus, Masekela also recorded with the Byrds and performed alongside stars such as Janis Joplin, Otis Redding and Jimi Hendrix at the famed 1967 Monterey Pop Festival.
Still performing 50 years on, he toured Europe in 2012 with Paul Simon to celebrate the 25th anniversary of his classic album "Graceland" in an African musical extravaganza.
He was married to singer and activist Miriam Makeba, known as "Mama Africa", from 1964 to 1966.
British Labour Party leader Jeremy Corbyn said in a tweet that Masekela was "a titan of jazz and of the anti-apartheid struggle".
"His courage, words and music inspired me, were heard across the world, and strengthened the resolve of those fighting for justice in South Africa."