Liverpool announced on Thursday it will take on city rivals Everton in the first Women's Super League game to be played at their historic home of Anfield on Nov. 17.
The fixture, part of the Women's Football Weekend during the next international break, will be the first time that Liverpool's women will play at the 54,074-capacity ground since an FA Cup semi-final defeat by Arsenal six years ago.
Liverpool Chief Executive Officer Peter Moore said the game would be a historic moment for women's football on Merseyside.
"We're incredibly proud to have our women's team play their first league game at Anfield and for it to be a Merseyside derby makes it extra special," he told the club's website. (http://bit.ly/2MGNtB2)
"Our fans now have the opportunity to watch our women's team at our spiritual home... it'll be a memorable occasion."
Liverpool's women usually play home matches at Prenton Park, the ground of Tranmere Rovers which has a capacity of 16,587.
The club said each adult who buys a 5 pound ticket could bring along three children below 16 years of age for free to encourage as many people as possible to attend the game.
Manchester City defeated local rivals Manchester United 1-0 in front of a record attendance for a Women's Super League game of 31,213 at the Etihad Stadium last month.
"It's a great chance for us to introduce our team to a whole new group of Reds supporters and, quite simply, we can't wait," Liverpool manager Vicky Jepson said.
Last season's Champions League semi-finalists Chelsea play Championship winners United while Tottenham Hotspur host Arsenal at their new stadium as part of the Women's Football Weekend.