More than 1 000 business, civil society and government leaders - including 10 heads of state - from more than 100 countries and 620 organisations will attend this year.
President Jacob Zuma, along with Deputy President Cyril Ramaphosa and Minister of Finance Malusi Gigaba, is expected to welcome the delegates officially.
Leaders from other countries who will attend include:
Edgar Chagwa Lungu, President of Zambia; Ameenah Gurib-Fakim, President of Mauritius; Emmanuel Issoze-Ngondet, Prime Minister of Gabon; Saara Kuugongelwa-Amadhila, Prime Minister of Namibia; Robert Mugabe, President of Zimbabwe; Yoweri Kaguta Museveni, President of Uganda; King Mswati III, King of Swaziland; Macky Sall, President of Senegal; Wolfgang Schäuble, German Federal Minister of Finance; and Brigitte Zypries, German Federal Minister of Economic Affairs and Energy.
Read also: WEF is a chance to woo investors